Epithelial tumours of the thymus

Epithelial tumours of the thymus include thymomas, thymic carcinomas and neuro-endocrine tumours. Rare, they nevertheless represent 20% of all mediastinal tumours and 50% of those located in the anterior mediastinum. Thymomas, in particular, can be associated to auto-immune disorders, among which pr...

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Bibliographic Details
Published in:Revue de pneumologie clinique 2010-02, Vol.66 (1), p.41-51
Main Authors: Thomas, P A, Payan-Defais, M J
Format: Article
Language:fre
Subjects:
Carcinoma, Neuroendocrine - mortality
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - radiotherapy
Carcinoma, Neuroendocrine - surgery
Combined Modality Therapy
Disease Progression
Humans
Myasthenia Gravis - pathology
Myasthenia Gravis - surgery
Neoplasm Invasiveness - pathology
Neoplasm Staging
Radiotherapy, Adjuvant
Survival Analysis
Thymoma - mortality
Thymoma - pathology
Thymoma - radiotherapy
Thymoma - surgery
Thymus Gland - pathology
Thymus Neoplasms - mortality
Thymus Neoplasms - pathology
Thymus Neoplasms - radiotherapy
Thymus Neoplasms - surgery
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Summary:Epithelial tumours of the thymus include thymomas, thymic carcinomas and neuro-endocrine tumours. Rare, they nevertheless represent 20% of all mediastinal tumours and 50% of those located in the anterior mediastinum. Thymomas, in particular, can be associated to auto-immune disorders, among which predominates myasthenia gravis. Their clinical behaviour varies widely, from a relative indolence to the potential of lymph node and/or systematic metastases. However, even patients with an invasive disease may have a long clinical history, explaining that a 10-year or 20-year survival from diagnosis does not imply a definitive cure. In daily practice, both the clinical Masaoka's staging system and the WHO histological classification condition the treatment strategies and allow to anticipate the prognosis. The initial treatment, as well as that of the recurrence, is based mainly on a complete resection. Postoperative radiotherapy is systematically added to the treatment of invasive tumours and/or to those with an aggressive histological subtype. Inoperable or metastatic tumours require a cisplatine and anthracyclin-based chemotherapy, followed by radical surgery and/or radiotherapy.
ISSN:0761-8417
DOI:10.1016/j.pneumo.2009.12.004