Influence of Magnolol on the bystander effect induced by alpha-particle irradiation

In this work, the influence of Magnolol on the bystander effect in alpha-particle irradiated Chinese hamster ovary (CHO) cells was examined. The bystander effect was studied through medium transfer experiments. Cytokinesis-block micronucleus (CBMN) assay was performed to quantify the chromosome dama...

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Bibliographic Details
Published in:Applied radiation and isotopes 2010-04, Vol.68 (4), p.718-721
Main Authors: Wong, T.P.W., Law, Y.L., Tse, A.K.W., Fong, W.F., Yu, K.N.
Format: Article
Language:English
Subjects:
Alpha Particles
Alpha-particle
Animals
Biphenyl Compounds - administration & dosage
Bystander effect
Bystander Effect - drug effects
Bystander Effect - radiation effects
CHO Cells
Chromosome Aberrations - drug effects
Chromosome Aberrations - radiation effects
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Lignans - administration & dosage
Magnolol
Radiation Tolerance - drug effects
Radiation-Protective Agents - administration & dosage
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Summary:In this work, the influence of Magnolol on the bystander effect in alpha-particle irradiated Chinese hamster ovary (CHO) cells was examined. The bystander effect was studied through medium transfer experiments. Cytokinesis-block micronucleus (CBMN) assay was performed to quantify the chromosome damage induced by alpha-particle irradiation. Our results showed that the alpha-particle induced micronuclei (MN) frequencies were suppressed with the presence of Magnolol.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.09.034