The Biomaterialbank of the German Competence Network of Heart Failure (CNHF) is a valuable resource for biomedical and genetic research

Abstract Genetic research on heart failure (HF) requires large cohorts of well-phenotyped patients. The German Competence Network of Heart Failure (CNHF) organized a biobank in 2004 to supply the necessary infrastructure and standard operating procedures (SOPs) for a centralized collection of blood...

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Bibliographic Details
Published in:International journal of cardiology 2009-07, Vol.136 (1), p.108-111
Main Authors: Posch, Maximilian G, Gelbrich, Götz, Pieske, Burkert, Lehmkuhl, Elke, Angermann, Christiane E, Störk, Stefan, Neumann, Till, Düngen, Hans-Dirk, Scheffold, Thomas, Müller-Tasch, Thomas, Maisch, Bernhard, Rauchhaus, Mathias, Dietz, Rainer, Özcelik, Cemil
Format: Article
Language:English
Subjects:
Biobank
Biomaterialbankfailure
Blood Banks - standards
Cardiovascular
Competence network
Databases, Genetic - standards
Germany
Heart Failure
Heart Failure - classification
Heart Failure - diagnosis
Heart Failure - genetics
Humans
Prospective Studies
Specimen Handling - methods
Specimen Handling - standards
Tissue Banks - standards
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Summary:Abstract Genetic research on heart failure (HF) requires large cohorts of well-phenotyped patients. The German Competence Network of Heart Failure (CNHF) organized a biobank in 2004 to supply the necessary infrastructure and standard operating procedures (SOPs) for a centralized collection of blood specimen. We centralized data and collected serum, plasma and DNA of well characterized HF subjects all over Germany. Different pseudonyms were created automatically to address data safety and other concerns about privacy. Thus far, we have collected 85,000 sample specimen from 9,500 prospectively evaluated patients with HF. Detailed medical data were prospectively acquired together with corresponding blood samples. In 2008 clinician-scientists can apply for access to the material. Our biobank represents a major facet of the CNHF and has already documented research and clinical utility.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2008.03.089