A theoretical and experimental study of the electrophoretic extraction of ions from a pressure driven flow in a microfluidic device

The electrophoretic extraction of ions from a hydrodynamic flow stream is investigated at an intersection between two microfluidic channels. A pressure gradient is used to drive samples through the main channel, while ions are electrophoretically extracted into the side channels. Hydrodynamic restri...

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Bibliographic Details
Published in:Lab on a chip 2009-01, Vol.9 (15), p.2203-2211
Main Authors: Reschke, Brent R, Luo, Hao, Schiffbauer, Jarrod, Edwards, Boyd F, Timperman, Aaron T
Format: Article
Language:English
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Summary:The electrophoretic extraction of ions from a hydrodynamic flow stream is investigated at an intersection between two microfluidic channels. A pressure gradient is used to drive samples through the main channel, while ions are electrophoretically extracted into the side channels. Hydrodynamic restrictors and a neutral coating are used to suppress bulk flow through the side channels. A theoretical model that assumes Poiseuille flow in the main channel and neglects molecular diffusion is used to calculate the extraction efficiency, eta, as a function of the ratio, R, of the average hydrodynamic velocity to the electrophoretic velocity. The model predicts complete extraction of ions (eta=1) for R
ISSN:1473-0197
1473-0189
DOI:10.1039/b823154k