Vitamin D-fence

The role of vitamin D in the immune system is complex. Vitamin D is produced in the skin following exposure to ultraviolet radiation. There is compelling evidence that vitamin D compounds protect against ultraviolet radiation-induced DNA damage and immune suppression, suggesting it may be beneficial...

Full description

Saved in:
Bibliographic Details
Published in:Photochemical & photobiological sciences 2010-04, Vol.9 (4), p.564-570
Main Authors: Dixon, Katie M., Sequeira, Vanessa B., Camp, Aaron J., Mason, Rebecca S.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomaterials
Chemistry
Humans
Immune Tolerance - immunology
Immune Tolerance - radiation effects
Immunologic Factors - immunology
Immunologic Factors - metabolism
Perspective
Physical Chemistry
Plant Sciences
Signal Transduction
Ultraviolet Rays - adverse effects
Vitamin D - biosynthesis
Vitamin D - immunology
Vitamin D - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of vitamin D in the immune system is complex. Vitamin D is produced in the skin following exposure to ultraviolet radiation. There is compelling evidence that vitamin D compounds protect against ultraviolet radiation-induced DNA damage and immune suppression, suggesting it may be beneficial as a skin cancer preventive agent. However, vitamin D has many modulatory effects on the immune system and it has in fact been suggested that the immune suppression generally attributed to the UVB portion of sunlight is mediated through vitamin D. Here we describe the role of vitamin D compounds as “defence” molecules against UVR-induced damage, and investigate both sides of the “fence” regarding the effects of vitamin D compounds and the immune system.
ISSN:1474-905X
1474-9092
DOI:10.1039/b9pp00184k