Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes

In this work, we reported that the quantum dot (QD) nanoparticles could be actively transported in the membrane nanotubes between cardiac myocytes. Single particle imaging and tracking of QDs revealed that most QDs moved in a bidirectional mode along the membrane nanotubes with a mean velocity of 1....

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Bibliographic Details
Published in:ACS nano 2010-06, Vol.4 (6), p.3015-3022
Main Authors: He, Kangmin, Luo, Wangxi, Zhang, Yuliang, Liu, Fei, Liu, Da, Xu, Li, Qin, Lei, Xiong, Chunyang, Lu, Zhizhen, Fang, Xiaohong, Zhang, Youyi
Format: Article
Language:English
Subjects:
Animals
Cell Membrane - chemistry
Diffusion
Drug Carriers - chemistry
Materials Testing
Nanotubes - chemistry
Particle Size
Quantum Dots
Rats
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Summary:In this work, we reported that the quantum dot (QD) nanoparticles could be actively transported in the membrane nanotubes between cardiac myocytes. Single particle imaging and tracking of QDs revealed that most QDs moved in a bidirectional mode along the membrane nanotubes with a mean velocity of 1.23 μm/s. The results suggested that QDs moving in the nanotubes were coordinately motivated by molecular motors. It provides new information for the study of intercellular transportation of nanoparticles.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn1002198