Inflammatory bowel disease: review from the aspect of genetics

Regardless of how inflammatory bowel disease (IBD) is defined, the term “genetic susceptibility” is always included. Due to substantial progress in the characterization of susceptible genes that interact with environmental influences, a number of review articles offering the latest insights continue...

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Bibliographic Details
Published in:Journal of gastroenterology 2009-11, Vol.44 (11), p.1097-1108
Main Authors: Ishihara, Shunji, Aziz, M. M, Yuki, Takafumi, Kazumori, Hideaki, Kinoshita, Yoshikazu
Format: Article
Language:English
Subjects:
Abdominal Surgery
Animals
Autophagy - genetics
Colorectal Surgery
Gastroenterology
Genetic Linkage
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Hepatology
Humans
Immunity, Innate
Inflammatory bowel disease
Inflammatory Bowel Diseases - genetics
Inflammatory Bowel Diseases - immunology
Medicine
Medicine & Public Health
Review
Surgical Oncology
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Summary:Regardless of how inflammatory bowel disease (IBD) is defined, the term “genetic susceptibility” is always included. Due to substantial progress in the characterization of susceptible genes that interact with environmental influences, a number of review articles offering the latest insights continue to be presented. To date, more than 30 novel IBD susceptible loci have been found, while several promising associations between IBD and gene variants have also been identified and replicated effectively. The present review highlights recent insights regarding linkage analysis and genome-wide association presented in studies of IBD susceptible genes, which provide additional evidence supporting their involvement in disease pathogenesis, based on linking to innate immune systems as a result of interactions with intestinal microbial flora. An improved understanding of IBD genetics will promote the identification of novel therapeutic agents, making it possible to identify environmental factors related to intestinal inflammation.
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-009-0141-8