Endocrine and metabolic effects of antiepileptic drugs

The antiepileptic drugs (AED) have been widely used for a great deal of people--in the treatment of epilepsy and other diseases--throughout the world. Continuous and prolonged use of AED may be associated with adverse effects in different systems, including a variety of endocrine and metabolic abnor...

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Bibliographic Details
Published in:Arquivos brasileiros de endocrinologia e metabologia 2009-10, Vol.53 (7), p.795-803
Main Authors: Bortolini, Luis Gustavo C, Kulak, Carolina A M, Borba, Victoria Z C, Silvado, Carlos E, Boguszewski, Cesar L
Format: Article
Language:Portuguese
Subjects:
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Body Weight - drug effects
Bone Density - drug effects
Diabetic Neuropathies - drug therapy
Endocrine Glands - drug effects
Endocrine Glands - metabolism
Humans
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Summary:The antiepileptic drugs (AED) have been widely used for a great deal of people--in the treatment of epilepsy and other diseases--throughout the world. Continuous and prolonged use of AED may be associated with adverse effects in different systems, including a variety of endocrine and metabolic abnormalities. In this review, the relationship of AED with alterations in bone mineral metabolism, energy balance and body weight, gonadal function and thyroid metabolism was revised, as well as their clinical utility in the treatment of diabetic neuropathy.
ISSN:1677-9487
DOI:10.1590/S0004-27302009000700002