Comparison of orbital floor triamcinolone acetonide and oral prednisolone for cataract surgery management in patients with non-infectious uveitis

Purpose To compare orbital floor triamcinolone acetonide and oral prednisolone in cataract surgery in patients with chronic non-infectious uveitis with regard to visual outcome, postoperative inflammation and macular edema. Methods Monocentric prospective randomized clinical trial with 40 eyes inclu...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2010-05, Vol.248 (5), p.715-720
Main Authors: Roesel, Martin, Heinz, Carsten, Koch, Joerg Michael, Heiligenhaus, Arnd
Format: Article
Language:English
Subjects:
Administration, Oral
Anterior Chamber - pathology
Cataract - complications
Cataract - physiopathology
Cataract - therapy
Female
Fluorescein Angiography
Glucocorticoids - administration & dosage
Humans
Inflammatory Disorders
Injections
Intraocular Pressure - physiology
Intraoperative Care
Lens Implantation, Intraocular
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Orbit
Phacoemulsification
Photometry
Postoperative Complications
Prednisolone - administration & dosage
Prospective Studies
Triamcinolone Acetonide - administration & dosage
Uveitis - complications
Uveitis - drug therapy
Uveitis - physiopathology
Visual Acuity - physiology
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Summary:Purpose To compare orbital floor triamcinolone acetonide and oral prednisolone in cataract surgery in patients with chronic non-infectious uveitis with regard to visual outcome, postoperative inflammation and macular edema. Methods Monocentric prospective randomized clinical trial with 40 eyes included. Patients underwent phacoemulsification with intraocular acrylic foldable lens (IOL) implantation. Patients were randomized either to intraoperative orbital floor triamcinolone acetonide (TA) (1 ml = 40 mg) (group 1, n  = 20), or to 4-week postoperative oral prednisolone (group 2, n  = 20). Laser flare photometry (LFM), cells in the anterior chamber (AC), best-corrected visual acuity (BCVA), IOL cell deposits, cystoid macular edema (CME) by means of fluorescein angiography, and central foveal thickness (OCT), posterior capsule opacification (PCO), and intraocular pressure (IOP) were analysed during a 6-months period. Results Mean BCVA postoperatively improved ( p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-009-1269-1