The effect of estrogens on plasma ghrelin concentrations in women

Background : Data regarding the possible effects of estrogen on ghrelin secretion in humans are limited and contradictory. Aim : To investigate the effect of estradiol (E2) on ghrelin levels in normal pre- and post-menopausal women. Subjects and methods : A total of 21 women divided into 3 groups, i...

Full description

Saved in:
Bibliographic Details
Published in:Journal of endocrinological investigation 2010-02, Vol.33 (2), p.109-112
Main Authors: Dafopoulos, K., Chalvatzas, N., Kosmas, G., Kallitsaris, A., Pournaras, S., Messinis, I. E.
Format: Article
Language:English
Subjects:
Acylation
Adult
Aged
Endocrinology
Estradiol - administration & dosage
Estradiol - analogs & derivatives
Estradiol - blood
Estrogens - administration & dosage
Fallopian Tubes - surgery
Female
Ghrelin - blood
Humans
Hysterectomy
Medicine
Medicine & Public Health
Menstrual Cycle - blood
Metabolic Diseases
Middle Aged
Original Articles
Ovariectomy
Postmenopause - blood
Premenopause - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background : Data regarding the possible effects of estrogen on ghrelin secretion in humans are limited and contradictory. Aim : To investigate the effect of estradiol (E2) on ghrelin levels in normal pre- and post-menopausal women. Subjects and methods : A total of 21 women divided into 3 groups, i.e.13 normally cycling women (no.=7, group 1 and no.=6, group 2) and 8 post-menopausal women (group 3). Women of group 1 received increasing doses of E2 through skin patches from cycle days 3 to 5. Women of group 2, underwent total abdominal hysterectomy plus bilateral salpingooophorectomy (TAH+BSO) on cycle day 3. Women of group 3 received po increasing doses of E2 valerate for 15 days. Acylated ghrelin and E2 were measured in all blood samples. Results : In group 1, plasma ghrelin levels did not show any significant changes for the week following cycle day 3. In group 2, ghrelin levels were similar before and after TAH+BSO and remained stable during the first 7 post-operative days. In group 3, no significant changes in plasma ghrelin levels were seen during the 15 days of E2 administration. Conclusions : The present study demonstrates for the first time that ghrelin values were not affected either by exogenous short-term estrogen administration to pre- and post-menopausal women or following ovariectomy in pre-menopausal women. It is suggested that ovarian hormones are not involved in the regulation of ghrelin secretion in women.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346563