Cu(II)-Mediated Methylthiolation of Aryl C−H Bonds with DMSO

An unprecedented Cu(II)-mediated methylthiolation of aryl C−H bonds under oxidative conditions that employs the widely available DMSO as the methylthiolation reagent is described. Various functional groups in the substrates were tolerated, and ethylthiolation was also successfully achieved directly...

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Bibliographic Details
Published in:Organic letters 2010-04, Vol.12 (7), p.1644-1647
Main Authors: Chu, Lingling, Yue, Xuyi, Qing, Feng-Ling
Format: Article
Language:English
Subjects:
Catalysis
Copper - chemistry
Dimethyl Sulfoxide - chemistry
Molecular Structure
Oxidation-Reduction
Stereoisomerism
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - chemistry
Sulfoxides - chemistry
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Summary:An unprecedented Cu(II)-mediated methylthiolation of aryl C−H bonds under oxidative conditions that employs the widely available DMSO as the methylthiolation reagent is described. Various functional groups in the substrates were tolerated, and ethylthiolation was also successfully achieved directly from diethyl sulfoxide under the same reaction conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100449c