Long-term outcome of vagus nerve stimulation for refractory partial epilepsy

We assessed 1- and 2-year outcomes of specific seizure types, quality of life, depression, and anxiety among patients treated with vagus nerve stimulation (VNS) for refractory partial epilepsy. Patients completed a seizure questionnaire, the Quality of Life in Epilepsy—89 (QOLIE-89) questionnaire, t...

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Bibliographic Details
Published in:Epilepsy & behavior 2003-06, Vol.4 (3), p.302-309
Main Authors: Chavel, Severine M, Westerveld, Michael, Spencer, Susan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anxiety - diagnosis
Anxiety - epidemiology
Anxiety - etiology
Depression - diagnosis
Depression - epidemiology
Depression - etiology
Electric Stimulation Therapy - instrumentation
Electric Stimulation Therapy - methods
Electrodes, Implanted
Employment
Epilepsies, Partial - classification
Epilepsies, Partial - psychology
Epilepsies, Partial - therapy
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Quality of Life
Refractory epilepsy
Seasons
Severity of Illness Index
Stimulation for epilepsy
Surveys and Questionnaires
Vagus Nerve - physiology
Vagus nerve stimulation
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Summary:We assessed 1- and 2-year outcomes of specific seizure types, quality of life, depression, and anxiety among patients treated with vagus nerve stimulation (VNS) for refractory partial epilepsy. Patients completed a seizure questionnaire, the Quality of Life in Epilepsy—89 (QOLIE-89) questionnaire, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory (BDI) at baseline and 1 year, and 2 years after activation of VNS. VNS was associated with ⩾50% reduction in total seizure frequency in 54% of patients at 1 year and 61% of patients 2 years post-VNS activation compared with baseline. No statistically significant changes from baseline to 12 or 24 months were found in mean quality of life, depression, or anxiety measures in the overall study population. Patients with at least 50% reduction in seizures had significant improvement in anxiety at 12 and 24 months compared with patients who did not have the same degree of seizure reduction.
ISSN:1525-5050
1525-5069
DOI:10.1016/S1525-5050(03)00109-4