Cerebral ischemic events after diagnosis of mitral valve prolapse: a community-based study of incidence and predictive factors

Association of mitral valve prolapse (MVP) with ischemic neurological events (INEs) is uncertain. In the community of Olmsted County (Minn), we identified all MVP diagnosed (1989 to 1998) in patients in sinus rhythm with no prior history of INE. We measured INE rates and compared them with expected...

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Bibliographic Details
Published in:Stroke (1970) 2003-06, Vol.34 (6), p.1339-1344
Main Authors: Avierinos, Jean-Francois, Brown, Robert D, Foley, David A, Nkomo, Vuyisile, Petty, George W, Scott, Christopher, Enriquez-Sarano, Maurice
Format: Article
Language:English
Subjects:
Age Factors
Aged
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Brain Ischemia - diagnosis
Brain Ischemia - epidemiology
Cerebral Infarction - diagnosis
Cerebral Infarction - epidemiology
Comorbidity
Echocardiography, Doppler
Electrocardiography
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Minnesota - epidemiology
Mitral Valve Prolapse - diagnosis
Mitral Valve Prolapse - epidemiology
Multivariate Analysis
Odds Ratio
Proportional Hazards Models
Risk
Risk Assessment
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Summary:Association of mitral valve prolapse (MVP) with ischemic neurological events (INEs) is uncertain. In the community of Olmsted County (Minn), we identified all MVP diagnosed (1989 to 1998) in patients in sinus rhythm with no prior history of INE. We measured INE rates and compared them with expected rates in our community to define the excess risk of INE. Among 777 eligible subjects (age, 49+/-20 years; 66% female; follow-up, 5.5+/-3.0 years), 30 patients had at least 1 INE during follow-up (at 10 years, 7+/-1%). Compared with expected INEs in the same community, subjects with MVP showed excess risk of lifetime INE (relative risk [RR], 2.2; 95% CI, 1.5 to 3.2; P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000072274.12041.FF