Lifespan of human lymphocyte subsets defined by CD45 isoforms

THE lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure 1 , retained by a long-lived cell, or by its...

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Bibliographic Details
Published in:Nature (London) 1992-11, Vol.360 (6401), p.264-265
Main Authors: Michie, Colin A, McLean, Angela, Alcock, Christopher, Beverley, Peter C. L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Aberrations
Chromosome Deletion
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Half-Life
Humanities and Social Sciences
Humans
Immunobiology
Immunologic Memory - radiation effects
letter
Leukocyte Common Antigens - metabolism
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
multidisciplinary
Science
Science (multidisciplinary)
T-Lymphocyte Subsets - radiation effects
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Summary:THE lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure 1 , retained by a long-lived cell, or by its progeny? Using the observation that T lymphocyte expression of isoforms of CD45 corresponds with their ability to respond to recall antigens, we have investigated the lifespan of both CD45RO (the subset containing responders, or 'memory' cells) and CD45RA (the unresponsive, or 'naive' subset) lymphocytes in a group of patients after radiotherapy. Here we report rapid loss of unstable chromosomes from the CD45RO but not the CD45RA pool. Immunological memory therefore apparently resides in a population with a more rapid rate of division. Differing survival curves for the two subsets are best described by a model in which there is also reversion in vivo from the CD45RO to the CD45RA phenotype. Expression of CD45RO in T cells may therefore be reversible.
ISSN:0028-0836
1476-4687
DOI:10.1038/360264a0