Effect of ageing on the number of neuronal noradrenaline uptake sites in the rat vas deferens

Previous work has shown an age-related reduction in neuronal uptake of noradrenaline in the prostatic, but not in the epididymal portion of the rat vas deferens. In the present paper, the influence of ageing on the number of [3H]desipramine binding sites and on the effect of lithium on neuronal [3H]...

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Published in:Naunyn-Schmiedeberg's archives of pharmacology 1992-10, Vol.346 (4), p.405-409
Main Authors: PEKELMANN MARKUS, R, WERNECK DE AVELLAR, M. C
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Binding Sites
Biological and medical sciences
Desipramine - metabolism
Fundamental and applied biological sciences. Psychology
Kinetics
Lithium - pharmacology
Male
Mammalian male genital system
Morphology. Physiology
Neurons - metabolism
Norepinephrine - metabolism
Rats
Rats, Wistar
Vas Deferens - drug effects
Vas Deferens - metabolism
Vertebrates: reproduction
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Summary:Previous work has shown an age-related reduction in neuronal uptake of noradrenaline in the prostatic, but not in the epididymal portion of the rat vas deferens. In the present paper, the influence of ageing on the number of [3H]desipramine binding sites and on the effect of lithium on neuronal [3H]noradrenaline uptake were studied in the prostatic and epididymal portions of vasa deferentia from 4- and 20-month-old rats. The affinity for [3H]desipramine (Kd values) in the epididymal and prostatic portions did not change with age. However, ageing reduced the maximal number of [3H]desipramine binding sites (Bmax values) in the prostatic, but not in the epididymal portion. Lithium potentiated neuronal [3H]noradrenaline uptake only in the prostatic portion and this potentiation was not changed by ageing. The results showed differences in neuronal noradrenaline uptake between the two portions of the vas deferens. Furthermore, the data suggest that the age-related reduction in neuronal uptake in the prostatic portion is due to a reduction in the number of neuronal uptake sites for noradrenaline.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00171082