What If Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-10, Vol.258 (5083), p.766-770
Main Author: McGarry, J. Denis
Format: Article
Language:English
Subjects:
3-Hydroxybutyric Acid
Acetoacetates - blood
Adipose Tissue - metabolism
Biological and medical sciences
Blood Glucose - metabolism
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty Acids, Nonesterified - blood
Fatty Acids, Nonesterified - metabolism
Glucose Tolerance Test
Humans
Hydroxybutyrates - blood
Hyperinsulinism
Insulin
Insulin - blood
Insulin Resistance
Islets of Langerhans - physiopathology
Ketone Bodies - blood
Ketone Bodies - metabolism
Lipid Metabolism
Lipid metabolism disorders
Lipidosis
Lipoproteins, VLDL - biosynthesis
Liver - metabolism
Medical sciences
Muscles
Nonesterified fatty acids
Physiological aspects
Triglycerides - metabolism
Type 1 diabetes mellitus
Type 2 diabetes mellitus
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Summary:Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1439783