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Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products
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| Published in: | Journal of pharmaceutical sciences 2010-05, Vol.99 (5), p.2200-2208 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5029-f2bda78b249b454ce9edf66eec63aad62bb0d509044d1688aaeac5715c5080943 |
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| cites | cdi_FETCH-LOGICAL-c5029-f2bda78b249b454ce9edf66eec63aad62bb0d509044d1688aaeac5715c5080943 |
| container_end_page | 2208 |
| container_issue | 5 |
| container_start_page | 2200 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 99 |
| creator | Carpenter, John F. Randolph, Theodore W. Jiskoot, Wim Crommelin, Daan J.A. Middaugh, C.Russell Winter, Gerhard |
| description | |
| doi_str_mv | 10.1002/jps.21989 |
| format | article |
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Pharm. Sci</addtitle><subject>analytical biochemistry</subject><subject>analytical ultracentrifugation</subject><subject>Biological and medical sciences</subject><subject>biophysical models</subject><subject>Chromatography, Gel - methods</subject><subject>Chromatography, Gel - standards</subject><subject>Drug Stability</subject><subject>General pharmacology</subject><subject>high‐performance/pressure liquid chromatography (HPLC)</subject><subject>Medical sciences</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical Preparations - standards</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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Drug treatments</topic><topic>physical stability</topic><topic>protein aggregation</topic><topic>protein formulation</topic><topic>Protein Stability</topic><topic>Quality Control</topic><topic>Recombinant Proteins - analysis</topic><topic>Recombinant Proteins - chemistry</topic><topic>Recombinant Proteins - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carpenter, John F.</creatorcontrib><creatorcontrib>Randolph, Theodore W.</creatorcontrib><creatorcontrib>Jiskoot, Wim</creatorcontrib><creatorcontrib>Crommelin, Daan J.A.</creatorcontrib><creatorcontrib>Middaugh, C.Russell</creatorcontrib><creatorcontrib>Winter, Gerhard</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carpenter, John F.</au><au>Randolph, Theodore W.</au><au>Jiskoot, Wim</au><au>Crommelin, Daan J.A.</au><au>Middaugh, C.Russell</au><au>Winter, Gerhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 2010-05, Vol.99 (5), p.2200-2208 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733438414 |
| source | ScienceDirect; Wiley Online Library - AutoHoldings Journals |
| subjects | analytical biochemistry analytical ultracentrifugation Biological and medical sciences biophysical models Chromatography, Gel - methods Chromatography, Gel - standards Drug Stability General pharmacology high‐performance/pressure liquid chromatography (HPLC) Medical sciences Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - standards Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments physical stability protein aggregation protein formulation Protein Stability Quality Control Recombinant Proteins - analysis Recombinant Proteins - chemistry Recombinant Proteins - standards |
| title | Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products |
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