Direct Azole Amination: CH Functionalization as a New Approach to Biologically Important Heterocycles

Three amigos: Direct oxidative amination of the C2‐position of azoles enables the synthesis of important classes of heterocycle in an efficient and atom‐economic manner (see scheme). Recent research has uncovered three distinct approaches to this transformation.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2010-03, Vol.49 (13), p.2282-2285
Main Authors: Armstrong, Alan, Collins, James C.
Format: Article
Language:English
Subjects:
Amination
Azoles - chemical synthesis
Azoles - chemistry
Carbon - chemistry
Chemistry, Pharmaceutical
copper
CH functionalization
heterocycles
Hydrogen - chemistry
Molecular Structure
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Description
Summary:Three amigos: Direct oxidative amination of the C2‐position of azoles enables the synthesis of important classes of heterocycle in an efficient and atom‐economic manner (see scheme). Recent research has uncovered three distinct approaches to this transformation.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200906750