An Updated Overview on Wnt Signaling Pathways: A Prelude for More

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for th...

Full description

Saved in:
Bibliographic Details
Published in:Circulation research 2010-06, Vol.106 (12), p.1798-1806
Main Authors: Rao, Tata Purushothama, Kühl, Michael
Format: Article
Language:English
Subjects:
Animals
beta Catenin - physiology
Biological and medical sciences
Cardiovascular System - embryology
Cardiovascular System - physiopathology
Cell Membrane - physiology
Frizzled Receptors - physiology
Fundamental and applied biological sciences. Psychology
Humans
Signal Transduction - physiology
Vertebrates: cardiovascular system
Wnt Proteins - physiology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c3315-b4d079045b3b5ccab9ccdeba6c42714a8428bcfa2afde128e3f7bcbd3caada993
container_end_page 1806
container_issue 12
container_start_page 1798
container_title Circulation research
container_volume 106
creator Rao, Tata Purushothama
Kühl, Michael
description Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem cell biology, cardiac development and differentiation, angiogenesis, cardiac hypertrophy, cardiac failure, and aging. Knowledge of growth factor signaling during differentiation will allow for improvement of targeted differentiation of embryonic or adult stem cells toward functional cardiomyocytes or for understanding the basis of diseases. Our major aim here is to provide a state of the art review summarizing our present knowledge of the intracellular Wnt-mediated signaling network. In particular, we provide evidence that the subdivision into canonical and noncanonical Wnt signaling pathways solely based on the identity of Wnt ligands or Frizzled receptors is not appropriate anymore. We thereby deliver a solid base for further upcoming articles of a review series focusing on the role of Wnt proteins on different aspects of cardiovascular development and dysfunction.
doi_str_mv 10.1161/CIRCRESAHA.110.219840
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733440048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733440048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3315-b4d079045b3b5ccab9ccdeba6c42714a8428bcfa2afde128e3f7bcbd3caada993</originalsourceid><addsrcrecordid>eNpFkU9v1DAQxS0EokvhI4B8QZxSxv82CbdoVWilolYtFUdrbE-6AW-y2ElX_fZktQs9jd7o92Y0bxh7L-BMiKX4vLq8Xd2e3zUXzazhTIq60vCCLYSRutCmFC_ZAgDqolQKTtibnH8BCK1k_ZqdSDDlstZywZqm5_fbgCMFfv1I6bGjHR96_rMf-V330GPs-gd-g-N6h0_5C2_4TaI4BeLtkPj3IdFb9qrFmOndsZ6y-6_nP1YXxdX1t8tVc1V4pYQpnA5Q1qCNU854j672PpDDpdeyFBorLSvnW5TYBhKyItWWzrugPGLAulan7NNh7jYNfybKo9102VOM2NMwZTvfqTWArmbSHEifhpwTtXabug2mJyvA7sOzz-HNGuwhvNn34bhhchsK_13_0pqBj0cAs8fYJux9l585WZcG1J7TB243xJFS_h2nHSW7Jozj2s5fAQVCFhIEwFIaKPYto_4CMPSHnw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733440048</pqid></control><display><type>article</type><title>An Updated Overview on Wnt Signaling Pathways: A Prelude for More</title><source>Freely Accessible Science Journals</source><creator>Rao, Tata Purushothama ; Kühl, Michael</creator><creatorcontrib>Rao, Tata Purushothama ; Kühl, Michael</creatorcontrib><description>Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem cell biology, cardiac development and differentiation, angiogenesis, cardiac hypertrophy, cardiac failure, and aging. Knowledge of growth factor signaling during differentiation will allow for improvement of targeted differentiation of embryonic or adult stem cells toward functional cardiomyocytes or for understanding the basis of diseases. Our major aim here is to provide a state of the art review summarizing our present knowledge of the intracellular Wnt-mediated signaling network. In particular, we provide evidence that the subdivision into canonical and noncanonical Wnt signaling pathways solely based on the identity of Wnt ligands or Frizzled receptors is not appropriate anymore. We thereby deliver a solid base for further upcoming articles of a review series focusing on the role of Wnt proteins on different aspects of cardiovascular development and dysfunction.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/CIRCRESAHA.110.219840</identifier><identifier>PMID: 20576942</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Animals ; beta Catenin - physiology ; Biological and medical sciences ; Cardiovascular System - embryology ; Cardiovascular System - physiopathology ; Cell Membrane - physiology ; Frizzled Receptors - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Signal Transduction - physiology ; Vertebrates: cardiovascular system ; Wnt Proteins - physiology</subject><ispartof>Circulation research, 2010-06, Vol.106 (12), p.1798-1806</ispartof><rights>2010 American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3315-b4d079045b3b5ccab9ccdeba6c42714a8428bcfa2afde128e3f7bcbd3caada993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=22975032$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20576942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rao, Tata Purushothama</creatorcontrib><creatorcontrib>Kühl, Michael</creatorcontrib><title>An Updated Overview on Wnt Signaling Pathways: A Prelude for More</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem cell biology, cardiac development and differentiation, angiogenesis, cardiac hypertrophy, cardiac failure, and aging. Knowledge of growth factor signaling during differentiation will allow for improvement of targeted differentiation of embryonic or adult stem cells toward functional cardiomyocytes or for understanding the basis of diseases. Our major aim here is to provide a state of the art review summarizing our present knowledge of the intracellular Wnt-mediated signaling network. In particular, we provide evidence that the subdivision into canonical and noncanonical Wnt signaling pathways solely based on the identity of Wnt ligands or Frizzled receptors is not appropriate anymore. We thereby deliver a solid base for further upcoming articles of a review series focusing on the role of Wnt proteins on different aspects of cardiovascular development and dysfunction.</description><subject>Animals</subject><subject>beta Catenin - physiology</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular System - embryology</subject><subject>Cardiovascular System - physiopathology</subject><subject>Cell Membrane - physiology</subject><subject>Frizzled Receptors - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Signal Transduction - physiology</subject><subject>Vertebrates: cardiovascular system</subject><subject>Wnt Proteins - physiology</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpFkU9v1DAQxS0EokvhI4B8QZxSxv82CbdoVWilolYtFUdrbE-6AW-y2ElX_fZktQs9jd7o92Y0bxh7L-BMiKX4vLq8Xd2e3zUXzazhTIq60vCCLYSRutCmFC_ZAgDqolQKTtibnH8BCK1k_ZqdSDDlstZywZqm5_fbgCMFfv1I6bGjHR96_rMf-V330GPs-gd-g-N6h0_5C2_4TaI4BeLtkPj3IdFb9qrFmOndsZ6y-6_nP1YXxdX1t8tVc1V4pYQpnA5Q1qCNU854j672PpDDpdeyFBorLSvnW5TYBhKyItWWzrugPGLAulan7NNh7jYNfybKo9102VOM2NMwZTvfqTWArmbSHEifhpwTtXabug2mJyvA7sOzz-HNGuwhvNn34bhhchsK_13_0pqBj0cAs8fYJux9l585WZcG1J7TB243xJFS_h2nHSW7Jozj2s5fAQVCFhIEwFIaKPYto_4CMPSHnw</recordid><startdate>20100625</startdate><enddate>20100625</enddate><creator>Rao, Tata Purushothama</creator><creator>Kühl, Michael</creator><general>American Heart Association, Inc</general><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100625</creationdate><title>An Updated Overview on Wnt Signaling Pathways: A Prelude for More</title><author>Rao, Tata Purushothama ; Kühl, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3315-b4d079045b3b5ccab9ccdeba6c42714a8428bcfa2afde128e3f7bcbd3caada993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>beta Catenin - physiology</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular System - embryology</topic><topic>Cardiovascular System - physiopathology</topic><topic>Cell Membrane - physiology</topic><topic>Frizzled Receptors - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Signal Transduction - physiology</topic><topic>Vertebrates: cardiovascular system</topic><topic>Wnt Proteins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, Tata Purushothama</creatorcontrib><creatorcontrib>Kühl, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, Tata Purushothama</au><au>Kühl, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Updated Overview on Wnt Signaling Pathways: A Prelude for More</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>2010-06-25</date><risdate>2010</risdate><volume>106</volume><issue>12</issue><spage>1798</spage><epage>1806</epage><pages>1798-1806</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem cell biology, cardiac development and differentiation, angiogenesis, cardiac hypertrophy, cardiac failure, and aging. Knowledge of growth factor signaling during differentiation will allow for improvement of targeted differentiation of embryonic or adult stem cells toward functional cardiomyocytes or for understanding the basis of diseases. Our major aim here is to provide a state of the art review summarizing our present knowledge of the intracellular Wnt-mediated signaling network. In particular, we provide evidence that the subdivision into canonical and noncanonical Wnt signaling pathways solely based on the identity of Wnt ligands or Frizzled receptors is not appropriate anymore. We thereby deliver a solid base for further upcoming articles of a review series focusing on the role of Wnt proteins on different aspects of cardiovascular development and dysfunction.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>20576942</pmid><doi>10.1161/CIRCRESAHA.110.219840</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0009-7330
ispartof Circulation research, 2010-06, Vol.106 (12), p.1798-1806
issn 0009-7330
1524-4571
language eng
recordid cdi_proquest_miscellaneous_733440048
source Freely Accessible Science Journals
subjects Animals
beta Catenin - physiology
Biological and medical sciences
Cardiovascular System - embryology
Cardiovascular System - physiopathology
Cell Membrane - physiology
Frizzled Receptors - physiology
Fundamental and applied biological sciences. Psychology
Humans
Signal Transduction - physiology
Vertebrates: cardiovascular system
Wnt Proteins - physiology
title An Updated Overview on Wnt Signaling Pathways: A Prelude for More
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T20%3A38%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Updated%20Overview%20on%20Wnt%20Signaling%20Pathways:%20A%20Prelude%20for%20More&rft.jtitle=Circulation%20research&rft.au=Rao,%20Tata%20Purushothama&rft.date=2010-06-25&rft.volume=106&rft.issue=12&rft.spage=1798&rft.epage=1806&rft.pages=1798-1806&rft.issn=0009-7330&rft.eissn=1524-4571&rft.coden=CIRUAL&rft_id=info:doi/10.1161/CIRCRESAHA.110.219840&rft_dat=%3Cproquest_cross%3E733440048%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3315-b4d079045b3b5ccab9ccdeba6c42714a8428bcfa2afde128e3f7bcbd3caada993%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=733440048&rft_id=info:pmid/20576942&rfr_iscdi=true