Central effects of ghrelin on the adrenal cortex: a morphological and hormonal study

Ghrelin, a growth hormone secretagogue that exerts an important role in appetite and weight regulation, participates in the activation of the hypothalamo-pituitary-adrenal (HPA) axis. Male Wistar rats (5/group) received daily for 5 days, via an ICV (intracerebroventricular) cannula, 5 microl phospha...

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Bibliographic Details
Published in:General physiology and biophysics 2010-06, Vol.29 (2), p.194-202
Main Authors: Milosević, Verica Lj, Stevanović, Darko M, Nesić, Dejan M, Sosić-Jurjević, Branka T, Ajdzanović, Vladimir Z, Starcević, Vesna P, Severs, Walter B
Format: Article
Language:English
Subjects:
Adrenal Cortex - anatomy & histology
Adrenal Cortex - drug effects
Adrenal Cortex - secretion
Adrenal Cortex Hormones - blood
Adrenal Cortex Hormones - secretion
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - secretion
Aldosterone - blood
Aldosterone - secretion
Animals
Body Weight - drug effects
Corticosterone - blood
Corticosterone - secretion
Eating - drug effects
Ghrelin - administration & dosage
Injections, Intraventricular
Male
Organ Size - drug effects
Rats
Rats, Wistar
Zona Fasciculata - anatomy & histology
Zona Fasciculata - drug effects
Zona Glomerulosa - anatomy & histology
Zona Glomerulosa - drug effects
Zona Reticularis - anatomy & histology
Zona Reticularis - drug effects
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Summary:Ghrelin, a growth hormone secretagogue that exerts an important role in appetite and weight regulation, participates in the activation of the hypothalamo-pituitary-adrenal (HPA) axis. Male Wistar rats (5/group) received daily for 5 days, via an ICV (intracerebroventricular) cannula, 5 microl phosphate buffered saline with or without 1 microg of rat ghrelin. Two hours after the last injection, blood and adrenal glands were collected from decapitated rats for blood hormone analyses and histologic and morphometric processing. Ghrelin treatment resulted in increased (p
ISSN:0231-5882
DOI:10.4149/gpb_2010_02_194