Structures and Antimicrobial Activities of Pyridoacridine Alkaloids Isolated from Different Chromotypes of the Ascidian Cystodytes dellechiajei

Three new pentacyclic alkaloids were isolated from different chromotypes of the western Mediterranean ascidian Cystodytes dellechiajei. The purple color morph collected in Catalonia contained the known compounds kuanoniamine D (1), shermilamine B (2), N-deacetylkuanoniamine D (3), and styelsamine C...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2010-06, Vol.73 (6), p.1044-1048
Main Authors: Bontemps, N, Bry, D, López-Legentil, S, Simon-Levert, A, Long, C, Banaigs, B
Format: Article
Language:English
Subjects:
Acridines - chemistry
Acridines - isolation & purification
Acridines - pharmacology
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Escherichia coli - drug effects
General pharmacology
Medical sciences
Microbial Sensitivity Tests
Micrococcus luteus - drug effects
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenanthrolines - chemistry
Phenanthrolines - isolation & purification
Phenanthrolines - pharmacology
Urochordata - chemistry
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Summary:Three new pentacyclic alkaloids were isolated from different chromotypes of the western Mediterranean ascidian Cystodytes dellechiajei. The purple color morph collected in Catalonia contained the known compounds kuanoniamine D (1), shermilamine B (2), N-deacetylkuanoniamine D (3), and styelsamine C (4) and a new alkaloid named N-deacetylshermilamine B (5). The green color morph collected in the Balearic Islands contained the known compounds 11-hydroxyascididemin (6) and 8,9-dihydro-11-hydroxyascididemin (7) and two new alkaloids named cystodimine A (8) and cystodimine B (9). The blue color morph collected in Catalonia yielded the known compound ascididemin (10). The structures of all compounds were elucidated on the basis of spectroscopic data, mainly 1D and 2D NMR data. The antimicrobial potential of the pyridoacridine alkaloids isolated from each color morph was evaluated and compared.
ISSN:0163-3864
1520-6025
DOI:10.1021/np900751k