Anti-ischemia Steroidal Saponins from the Seeds of Allium fistulosum

Six new furostanol saponins (1−6), named fistulosaponins A−F, three known furostanol saponins (7−9), and seven known aromatic compounds were isolated from seeds of Welsh onion (Allium fistulosum). The structures of these compounds were characterized by spectroscopic analyses including 2D NMR spectro...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2010-06, Vol.73 (6), p.1053-1057
Main Authors: Lai, Wei, Wu, Zhijun, Lin, Houwen, Li, Tiejun, Sun, Lianna, Chai, Yifeng, Chen, Wansheng
Format: Article
Language:English
Subjects:
Aroma and flavouring agent industries
Biological and medical sciences
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Endothelial Cells - drug effects
Food industries
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
Ischemia - drug therapy
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Onions - chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Seeds - chemistry
Sterols - chemistry
Sterols - isolation & purification
Sterols - pharmacology
Umbilical Veins - cytology
Umbilical Veins - drug effects
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Summary:Six new furostanol saponins (1−6), named fistulosaponins A−F, three known furostanol saponins (7−9), and seven known aromatic compounds were isolated from seeds of Welsh onion (Allium fistulosum). The structures of these compounds were characterized by spectroscopic analyses including 2D NMR spectroscopy, mass spectrometry, and acid hydrolysis. The protective effect of the saponins on hypoxia-induced human umbilical vein endothelial cell injury was evaluated.
ISSN:0163-3864
1520-6025
DOI:10.1021/np900815p