Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii

The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and b-sitosterol glucopy...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2010-05, Vol.24 (5), p.775-777
Main Authors: Wansi, Jean Duplex, Hussain, Hidayat, Tcho, Alain Tadjong, Kouam, Simeon F, Specht, Sabine, Sarite, Salem Ramadan, Hoerauf, Achim, Krohn, Karsten
Format: Article
Language:English
Subjects:
Alkaloids - isolation & purification
Alkaloids - pharmacology
Antimalarials - isolation & purification
Antimalarials - pharmacology
antiplasmodial activity
Biological and medical sciences
Dioxoles
Furans - isolation & purification
Furans - pharmacology
furoquinoline alkaloids
General pharmacology
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Bark - chemistry
Plant Extracts - pharmacology
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Quinolines - isolation & purification
Quinolines - pharmacology
Rutaceae
Rutaceae - chemistry
Teclea afzelii
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and b-sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1-4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
1099-1573
DOI:10.1002/ptr.2894