Adiponectin Multimers and ADIPOQ T45G in Coronary Artery Disease in Caribbean Type 2 Diabetic Subjects of African Descent

• Published in: Obesity (Silver Spring, Md.) Md.), 2010-07, Vol.18 (7), p.1466-1468
• Main Authors: Foucan, Lydia, Ezourhi, Nabila, Maimaitiming, Suliya, Hedreville, Segho, Inamo, Jocelyn, Atallah, Andre, Bangou‐Bredent, Jacqueline, Aubert, Roberte, Chout, Roger, Fumeron, Frederic, Donnet, Jean‐Paul, Marre, Michel
• Format: Article
• Language: English
• Subjects: Adiponectin - chemistry; Adiponectin - genetics; African Continental Ancestry Group - genetics; African Continental Ancestry Group - statistics & numerical data; Aged; Blood pressure; Cardiovascular disease; Cholesterol; Cholesterol, HDL - blood; Coronary Artery Disease - ethnology; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Coronary vessels; Cross-sectional studies; Diabetes; Diabetes Mellitus, Type 2 - ethnology; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Epidemiology; Female; Genotype; Heart attacks; Hospitals; Humans; Logistic Models; Male; Males; Metabolic syndrome; Middle Aged; Molecular Weight; Polymorphism; Polymorphism, Genetic; Regression analysis; Triglycerides - blood; Vein & artery diseases; West Indies - epidemiology
• ISSN: 1930-7381; 1930-739X
• DOI: 10.1038/oby.2009.441

Ethnic differences may affect the association of adiponectin (Ad) multimers with coronary artery disease (CAD). We analyzed the associations of total Ad, Ad multimers, and T45G polymorphism of ADIPOQ gene with pre‐existing CAD. We carried out a cross‐sectional study of 216 Afro‐Caribbean type 2 diabetic (T2D) subjects. Levels of total Ad, high molecular weight (HMW), middle molecular weight (MMW), and low molecular weight (LMW) isoforms were measured. Subjects were genotyped. Of the subjects studied, 57 had pre‐existing CAD, 77% of whom have had myocardial infarction. Subjects with CAD had lower Ad levels (total and multimers) and a higher frequency carried the minor allele 45G, GG/TG, (18% vs. 8%, P = 0.03) than subjects without CAD. In logistic regression analysis, the models used evaluate Ad in the context of adjustment for metabolic syndrome characteristics. The adjusted odds ratio (OR) of CAD was increased significantly (by factors of 1.05–3.27) for males, older subjects, low high‐density lipoprotein cholesterol (HDL‐C), high triglycerides (TGs), and carriers of the 45 G allele. For Ad, in model 1 (including only total Ad) the adjusted OR was 2.30; P = 0.03 and, in model 2 (including the three multimers, but not total Ad), the adjusted ORs were 0.73; P = 0.52 (HMW), 2.90; P = 0.01 (MMW), and 2.08; P = 0.09 (LMW). The T45G polymorphism in the ADIPOQ gene and hypoadiponectinemia were associated with CAD in our T2D subjects of predominantly African background. This effect of Ad level was mainly related to the MMW Ad form.