An Antiplatelet Aggregation Principle and X-Ray Structural Analysis of cis-Khellactone Diester from Peucedanum japonicum

Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3'-isovaleryl-4'-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ri...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1992-10, Vol.55 (10), p.1396-1401
Main Authors: Jong, Ting-Ting, Hwang, Hwey-Ching, Jean, Meei-Yueh, Wu, Tian-Shung, Teng, Che-Ming
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
CIENCIAS MEDICAS
COUMARINE
COUMARINS
Coumarins - chemistry
Coumarins - isolation & purification
Coumarins - pharmacology
CUMARINAS
Drugs, Chinese Herbal
FARMACOLOGIA
FOLK MEDICINE
General pharmacology
Magnetic Resonance Spectroscopy
MEDICAL SCIENCES
MOLECULAR STRUCTURE
PHARMACODYNAMICS
Pharmacognosy. Homeopathy. Health food
PHARMACOLOGIE
PHARMACOLOGY
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Platelet Aggregation Inhibitors - chemistry
Platelet Aggregation Inhibitors - isolation & purification
Platelet Aggregation Inhibitors - pharmacology
PLATELETS
Rabbits
RAYON X
RAYOS-X
SCIENCES MEDICALES
STRUCTURE
TAIWAN
THROMBOCYTE
TROMBOCITOS
UMBELLIFERAE
X RADIATION
X RAYS
X-Ray Diffraction
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3'-isovaleryl-4'-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3',4'-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3',4'-diisovalerylkhellactone [1] showed significant activity (at 50 micrograms/ml).
ISSN:0163-3864
1520-6025
DOI:10.1021/np50088a002