Small RNA-mediated regulation at the level of transcript stability

In recent years, bacterial small regulatory RNAs (sRNAs) have been demonstrated to be powerful modulators of gene expression. Whether it is by modulating mRNA functions or protein activities, sRNAs often employ unexpected and extremely diverse mechanisms to modify the genetic output. Although the fi...

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Bibliographic Details
Published in:RNA biology 2010-03, Vol.7 (2), p.140-144
Main Authors: Caron, Marie-Pier, Lafontaine, Daniel A., Massé, Eric
Format: Article
Language:English
Subjects:
Bacteria - genetics
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Gene Expression Regulation, Bacterial
Landes
MicroRNAs - metabolism
Organogenesis
Proteins
RNA Stability - genetics
RNA, Bacterial - metabolism
RNA, Small Interfering - metabolism
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Summary:In recent years, bacterial small regulatory RNAs (sRNAs) have been demonstrated to be powerful modulators of gene expression. Whether it is by modulating mRNA functions or protein activities, sRNAs often employ unexpected and extremely diverse mechanisms to modify the genetic output. Although the first sRNAs were characterized as molecules blocking translation of specific target mRNAs, this review will focus on an emerging subset of sRNAs that promote the decay of their target mRNAs. While the outcome resembles the RNAi silencing described in eukaryotes, the mechanism of bacterial sRNAs differs fundamentally. These sRNAs are the subject of intensive studies, which makes them the best characterized sRNAs to date.
ISSN:1547-6286
1555-8584
DOI:10.4161/rna.7.2.11056