Enantioseparation of benzazoles and benzanilides on polysaccharide-based chiral columns

The chiral recognition ability of the polysaccharide‐based chiral columns (Chiralpak AD‐RH, Chiralpak AS‐RJ, Chiralpak IC, Chiralcel OD‐RH, and Chiralcel OJ‐RH) for the benzazoles and the benzanilides was evaluated under reversed phase conditions. The columns showed the high chiral recognition abili...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 2010-05, Vol.22 (4), p.382-388
Main Authors: Kubota, Takateru, Sawada, Naotaka, Zhou, Lili, Welch, Christopher J.
Format: Article
Language:English
Subjects:
Amylose - analogs & derivatives
Amylose - chemistry
Anilides - chemistry
benzanilide
benzazole
Benzoates - chemistry
Carbamates - chemistry
Cellulose - analogs & derivatives
Cellulose - chemistry
Chemistry Techniques, Analytical - methods
chiral HPLC
Chirality
Chromatography, High Pressure Liquid - methods
Chromatography, Ion Exchange - instrumentation
Chromatography, Ion Exchange - methods
Indoles - chemistry
Integrated circuits
Models, Chemical
Phenylcarbamates - chemistry
polysaccharide
Polysaccharides - chemistry
Recognition
Reproduction
resolution
Stereoisomerism
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Summary:The chiral recognition ability of the polysaccharide‐based chiral columns (Chiralpak AD‐RH, Chiralpak AS‐RJ, Chiralpak IC, Chiralcel OD‐RH, and Chiralcel OJ‐RH) for the benzazoles and the benzanilides was evaluated under reversed phase conditions. The columns showed the high chiral recognition ability for a wide range of benzazoles and benzanilides. Twenty‐one racemates were used for the evaluation, and 20 racemates were completely separated on at least one of the columns. In particular, AS‐RH and OJ‐RH showed the high chiral recognition ability for the benzazoles, and the AD‐RH, IC, and OJ‐RH were effective for the benzanilides. Chirality 2010. © 2009 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.20732