Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes

The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi‐billion dollar drug, simvastatin (Zocor™). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels‐A...

Full description

Saved in:
Bibliographic Details
Published in:Biopolymers 2010-09, Vol.93 (9), p.755-763
Main Authors: Campbell, Chantel D., Vederas, John C.
Format: Article
Language:English
Subjects:
biosynthesis
Cytochalasins - biosynthesis
Cytochalasins - chemistry
Diels Alderase
enzyme
Lactones - chemistry
Lactones - metabolism
Lovastatin - analogs & derivatives
Lovastatin - biosynthesis
Lovastatin - chemistry
natural product
polyketide
Polyketide Synthases - metabolism
Pyrrolidinones - chemistry
Pyrrolidinones - metabolism
RNA, Catalytic - metabolism
Simvastatin - chemical synthesis
Simvastatin - chemistry
Tetrahydronaphthalenes - chemistry
Tetrahydronaphthalenes - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi‐billion dollar drug, simvastatin (Zocor™). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels‐Alderase enzyme activity is utilized in its biosynthesis. This review examines the biosynthesis of lovastatin, as well as of compactin, equisetin, cytochalasins, and solanapyrones, which are other structurally related polyketides that appear to utilize a Diels‐Alderase. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 755–763, 2010.
ISSN:0006-3525
1097-0282
DOI:10.1002/bip.21428