Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity

Dendritic cells are professional antigen‐presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell...

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Bibliographic Details
Published in:The EMBO journal 2003-06, Vol.22 (11), p.2546-2551
Main Authors: Ricciardi-Castagnoli, Paola, Granucci, Francesca, Zanoni, Ivan, Feau, Sonia
Format: Article
Language:English
Subjects:
adaptive immune response
Animals
B-Lymphocytes - immunology
Cell Communication
Cell Differentiation
dendritic cells
Dendritic Cells - cytology
Dendritic Cells - immunology
EMBO19
EMBO37
Humans
Immunity, Innate
innate immune response
interleukin 2
Interleukin-2 - physiology
Killer Cells, Natural - immunology
Models, Immunological
New EMBO Member's Review
regulatory T cells
T-Lymphocytes - immunology
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Summary:Dendritic cells are professional antigen‐presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T‐ and B‐cell responses and the relevance of interleukin 2 in these processes.
ISSN:0261-4189
1460-2075
DOI:10.1093/emboj/cdg261