Preparation of Unidirectional End-Grafted α-Helical Polypeptides by Solvent Quenching

A simple “solvent quenching” approach to align an α-helical end-grafted poly(γ-benzyl l-glutamate) monolayer is presented. By sequentially treating poly(γ-benzyl l-glutamate) with good solvent (chloroform) and bad solvent (acetone), we obtained a highly aligned monolayer with an average tilt angle a...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2003-05, Vol.125 (21), p.6376-6377
Main Authors: Wang, Yuli, Chang, Ying Chih
Format: Article
Language:English
Subjects:
Acetone - chemistry
Applied sciences
Chloroform - chemistry
Exact sciences and technology
Microscopy, Atomic Force
Organic polymers
Physicochemistry of polymers
Polyglutamic Acid - analogs & derivatives
Polyglutamic Acid - chemistry
Properties and characterization
Protein Structure, Secondary
Solvents - chemistry
Spectroscopy, Fourier Transform Infrared
Surface properties
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Summary:A simple “solvent quenching” approach to align an α-helical end-grafted poly(γ-benzyl l-glutamate) monolayer is presented. By sequentially treating poly(γ-benzyl l-glutamate) with good solvent (chloroform) and bad solvent (acetone), we obtained a highly aligned monolayer with an average tilt angle as small as 3°.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja034428k