Fiber bed reactor design for animal cell culture

A design is presented in which cells are immobilized within a bed of glass fibers and are fed by continuous perfusion of liquid medium. The advantages of the design are first supported by a consideration of previously published data and theoretical relationships developed for fibrous beds. Next, exp...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1989-06, Vol.34 (1), p.1-9
Main Authors: Perry, Steven D., Wang, Daniel I. C.
Format: Article
Language:English
Subjects:
Animal cells
Biological and medical sciences
Biotechnology
Establishment of new cell lines, improvement of cultural methods, mass cultures
Eukaryotic cell cultures
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
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Summary:A design is presented in which cells are immobilized within a bed of glass fibers and are fed by continuous perfusion of liquid medium. The advantages of the design are first supported by a consideration of previously published data and theoretical relationships developed for fibrous beds. Next, experimental results based on this design are presented. Finally, unexpected productivity increases that appear to be unique to the fiber bed design are discussed.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.260340102