Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate-limited growth conditions

Experiments performed in batch fermentation under phosphate‐limited growth conditions showed that the citric acid yield was inversely related to the excess nitrogen concentration in the medium. Results from chemostat culture confirmed a negative relationship between the citric acid yield and both th...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1989-05, Vol.33 (11), p.1500-1504
Main Authors: Dawson, M. W., Maddox, I. S., Brooks, J. D.
Format: Article
Language:English
Subjects:
acide citrique
acido citrico
aspergillus
azote
Biological and medical sciences
Biotechnology
catabolism
catabolisme
catabolismo
citric acid
fermentacion
fermentation
fosfatos
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
nitrogen
nitrogeno
phosphate
phosphates
produccion
production
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Summary:Experiments performed in batch fermentation under phosphate‐limited growth conditions showed that the citric acid yield was inversely related to the excess nitrogen concentration in the medium. Results from chemostat culture confirmed a negative relationship between the citric acid yield and both the specific growth rate and the nitrogen consumption rate. This is evidence for nitrogen catabolite repression. A fed‐batch fermentation performed under dual phosphate/nitrogen limitation produced results very similar to those from a culture limited by nitrogen alone. There is no advantage in maintaining an excess of phosphate during citric acid production and the process will therefore be more economic when operated under dual limitation conditions.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.260331119