Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate-limited growth conditions

Experiments performed in batch fermentation under phosphate‐limited growth conditions showed that the citric acid yield was inversely related to the excess nitrogen concentration in the medium. Results from chemostat culture confirmed a negative relationship between the citric acid yield and both th...

Full description

Saved in:
Bibliographic Details
Published in:Biotechnology and bioengineering 1989-05, Vol.33 (11), p.1500-1504
Main Authors: Dawson, M. W., Maddox, I. S., Brooks, J. D.
Format: Article
Language:English
Subjects:
acide citrique
acido citrico
aspergillus
azote
Biological and medical sciences
Biotechnology
catabolism
catabolisme
catabolismo
citric acid
fermentacion
fermentation
fosfatos
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
nitrogen
nitrogeno
phosphate
phosphates
produccion
production
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5039-360e107d654c7fcf552f54413b7907c81817d42005954a38562dbac4522bc163
cites cdi_FETCH-LOGICAL-c5039-360e107d654c7fcf552f54413b7907c81817d42005954a38562dbac4522bc163
container_end_page 1504
container_issue 11
container_start_page 1500
container_title Biotechnology and bioengineering
container_volume 33
creator Dawson, M. W.
Maddox, I. S.
Brooks, J. D.
description Experiments performed in batch fermentation under phosphate‐limited growth conditions showed that the citric acid yield was inversely related to the excess nitrogen concentration in the medium. Results from chemostat culture confirmed a negative relationship between the citric acid yield and both the specific growth rate and the nitrogen consumption rate. This is evidence for nitrogen catabolite repression. A fed‐batch fermentation performed under dual phosphate/nitrogen limitation produced results very similar to those from a culture limited by nitrogen alone. There is no advantage in maintaining an excess of phosphate during citric acid production and the process will therefore be more economic when operated under dual limitation conditions.
doi_str_mv 10.1002/bit.260331119
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733498240</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733498240</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5039-360e107d654c7fcf552f54413b7907c81817d42005954a38562dbac4522bc163</originalsourceid><addsrcrecordid>eNp9kk9vFCEchonR2LV69Go4mPQ0lT_DAMe21m6Tpk3aNSZeCAPMLDo7jDDTut_Ajy2bnWw9eYEQnt_LkzcA8B6jU4wQ-VT78ZRUiFKMsXwBFhhJXiAi0UuwQAhVBWWSHIE3Kf3IRy6q6jU4woIJLiRZgD-Xj9663jjYhAh7P8bQuh4aPeo6dH50MLohupR86KGdou9baDLlDdTGWzjEYCcz7m7rLTxLg4ut77op5azWRTj1Nq_DOqRhrUdXdH6TQy1sY3ga19CE3vrddHoLXjW6S-7dvB-D1ZfL1cWyuLm7ur44uykMQ1QWtEIOI24rVhremIYx0rCyxLTmEnEjsMDclgQhJlmpqWAVsbU2JSOkNriix-BkH5vFf00ujWrjk3Fdp3sXpqQ4paUUpESZLPakiSGl6Bo1RL_RcaswUrvqVa5eHarP_Ic5eao3zj7Tc9cZ-DgDOhndNVH3xqcDx4mgVIiM8T325Du3_f-j6vx69a_BbOzT6H4fJnX8qSpOOVPfbq_Uw-fb--9LvlTnz8aNDkq3Mct8fcBS5n-CMUWE_gVJnbZ2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733498240</pqid></control><display><type>article</type><title>Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate-limited growth conditions</title><source>Wiley-Blackwell Journals (Backfile Content)</source><creator>Dawson, M. W. ; Maddox, I. S. ; Brooks, J. D.</creator><creatorcontrib>Dawson, M. W. ; Maddox, I. S. ; Brooks, J. D. ; Massey University, Palmerston North, New Zealand</creatorcontrib><description>Experiments performed in batch fermentation under phosphate‐limited growth conditions showed that the citric acid yield was inversely related to the excess nitrogen concentration in the medium. Results from chemostat culture confirmed a negative relationship between the citric acid yield and both the specific growth rate and the nitrogen consumption rate. This is evidence for nitrogen catabolite repression. A fed‐batch fermentation performed under dual phosphate/nitrogen limitation produced results very similar to those from a culture limited by nitrogen alone. There is no advantage in maintaining an excess of phosphate during citric acid production and the process will therefore be more economic when operated under dual limitation conditions.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.260331119</identifier><identifier>PMID: 18587892</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>acide citrique ; acido citrico ; aspergillus ; azote ; Biological and medical sciences ; Biotechnology ; catabolism ; catabolisme ; catabolismo ; citric acid ; fermentacion ; fermentation ; fosfatos ; Fundamental and applied biological sciences. Psychology ; Methods. Procedures. Technologies ; Microbial engineering. Fermentation and microbial culture technology ; nitrogen ; nitrogeno ; phosphate ; phosphates ; produccion ; production</subject><ispartof>Biotechnology and bioengineering, 1989-05, Vol.33 (11), p.1500-1504</ispartof><rights>Copyright © 1989 John Wiley &amp; Sons, Inc.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5039-360e107d654c7fcf552f54413b7907c81817d42005954a38562dbac4522bc163</citedby><cites>FETCH-LOGICAL-c5039-360e107d654c7fcf552f54413b7907c81817d42005954a38562dbac4522bc163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbit.260331119$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbit.260331119$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27924,27925,46049,46473</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=7283388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18587892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dawson, M. W.</creatorcontrib><creatorcontrib>Maddox, I. S.</creatorcontrib><creatorcontrib>Brooks, J. D.</creatorcontrib><creatorcontrib>Massey University, Palmerston North, New Zealand</creatorcontrib><title>Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate-limited growth conditions</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>Experiments performed in batch fermentation under phosphate‐limited growth conditions showed that the citric acid yield was inversely related to the excess nitrogen concentration in the medium. Results from chemostat culture confirmed a negative relationship between the citric acid yield and both the specific growth rate and the nitrogen consumption rate. This is evidence for nitrogen catabolite repression. A fed‐batch fermentation performed under dual phosphate/nitrogen limitation produced results very similar to those from a culture limited by nitrogen alone. There is no advantage in maintaining an excess of phosphate during citric acid production and the process will therefore be more economic when operated under dual limitation conditions.</description><subject>acide citrique</subject><subject>acido citrico</subject><subject>aspergillus</subject><subject>azote</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>catabolism</subject><subject>catabolisme</subject><subject>catabolismo</subject><subject>citric acid</subject><subject>fermentacion</subject><subject>fermentation</subject><subject>fosfatos</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbial engineering. Fermentation and microbial culture technology</subject><subject>nitrogen</subject><subject>nitrogeno</subject><subject>phosphate</subject><subject>phosphates</subject><subject>produccion</subject><subject>production</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNp9kk9vFCEchonR2LV69Go4mPQ0lT_DAMe21m6Tpk3aNSZeCAPMLDo7jDDTut_Ajy2bnWw9eYEQnt_LkzcA8B6jU4wQ-VT78ZRUiFKMsXwBFhhJXiAi0UuwQAhVBWWSHIE3Kf3IRy6q6jU4woIJLiRZgD-Xj9663jjYhAh7P8bQuh4aPeo6dH50MLohupR86KGdou9baDLlDdTGWzjEYCcz7m7rLTxLg4ut77op5azWRTj1Nq_DOqRhrUdXdH6TQy1sY3ga19CE3vrddHoLXjW6S-7dvB-D1ZfL1cWyuLm7ur44uykMQ1QWtEIOI24rVhremIYx0rCyxLTmEnEjsMDclgQhJlmpqWAVsbU2JSOkNriix-BkH5vFf00ujWrjk3Fdp3sXpqQ4paUUpESZLPakiSGl6Bo1RL_RcaswUrvqVa5eHarP_Ic5eao3zj7Tc9cZ-DgDOhndNVH3xqcDx4mgVIiM8T325Du3_f-j6vx69a_BbOzT6H4fJnX8qSpOOVPfbq_Uw-fb--9LvlTnz8aNDkq3Mct8fcBS5n-CMUWE_gVJnbZ2</recordid><startdate>198905</startdate><enddate>198905</enddate><creator>Dawson, M. W.</creator><creator>Maddox, I. S.</creator><creator>Brooks, J. D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198905</creationdate><title>Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate-limited growth conditions</title><author>Dawson, M. W. ; Maddox, I. S. ; Brooks, J. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5039-360e107d654c7fcf552f54413b7907c81817d42005954a38562dbac4522bc163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>acide citrique</topic><topic>acido citrico</topic><topic>aspergillus</topic><topic>azote</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>catabolism</topic><topic>catabolisme</topic><topic>catabolismo</topic><topic>citric acid</topic><topic>fermentacion</topic><topic>fermentation</topic><topic>fosfatos</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Methods. Procedures. Technologies</topic><topic>Microbial engineering. Fermentation and microbial culture technology</topic><topic>nitrogen</topic><topic>nitrogeno</topic><topic>phosphate</topic><topic>phosphates</topic><topic>produccion</topic><topic>production</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dawson, M. W.</creatorcontrib><creatorcontrib>Maddox, I. S.</creatorcontrib><creatorcontrib>Brooks, J. D.</creatorcontrib><creatorcontrib>Massey University, Palmerston North, New Zealand</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dawson, M. W.</au><au>Maddox, I. S.</au><au>Brooks, J. D.</au><aucorp>Massey University, Palmerston North, New Zealand</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate-limited growth conditions</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol. Bioeng</addtitle><date>1989-05</date><risdate>1989</risdate><volume>33</volume><issue>11</issue><spage>1500</spage><epage>1504</epage><pages>1500-1504</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>Experiments performed in batch fermentation under phosphate‐limited growth conditions showed that the citric acid yield was inversely related to the excess nitrogen concentration in the medium. Results from chemostat culture confirmed a negative relationship between the citric acid yield and both the specific growth rate and the nitrogen consumption rate. This is evidence for nitrogen catabolite repression. A fed‐batch fermentation performed under dual phosphate/nitrogen limitation produced results very similar to those from a culture limited by nitrogen alone. There is no advantage in maintaining an excess of phosphate during citric acid production and the process will therefore be more economic when operated under dual limitation conditions.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18587892</pmid><doi>10.1002/bit.260331119</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0006-3592
ispartof Biotechnology and bioengineering, 1989-05, Vol.33 (11), p.1500-1504
issn 0006-3592
1097-0290
language eng
recordid cdi_proquest_miscellaneous_733498240
source Wiley-Blackwell Journals (Backfile Content)
subjects acide citrique
acido citrico
aspergillus
azote
Biological and medical sciences
Biotechnology
catabolism
catabolisme
catabolismo
citric acid
fermentacion
fermentation
fosfatos
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
nitrogen
nitrogeno
phosphate
phosphates
produccion
production
title Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate-limited growth conditions
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A11%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evidence%20for%20nitrogen%20catabolite%20repression%20during%20citric%20acid%20production%20by%20Aspergillus%20niger%20under%20phosphate-limited%20growth%20conditions&rft.jtitle=Biotechnology%20and%20bioengineering&rft.au=Dawson,%20M.%20W.&rft.aucorp=Massey%20University,%20Palmerston%20North,%20New%20Zealand&rft.date=1989-05&rft.volume=33&rft.issue=11&rft.spage=1500&rft.epage=1504&rft.pages=1500-1504&rft.issn=0006-3592&rft.eissn=1097-0290&rft.coden=BIBIAU&rft_id=info:doi/10.1002/bit.260331119&rft_dat=%3Cproquest_cross%3E733498240%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5039-360e107d654c7fcf552f54413b7907c81817d42005954a38562dbac4522bc163%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=733498240&rft_id=info:pmid/18587892&rfr_iscdi=true