Inhibitory and bactericidal activities of gemifloxacin and other antimicrobials against Mycoplasma pneumoniae

The MIC of gemifloxacin was compared with that of sparfloxacin, levofloxacin, moxifloxacin, gatifloxacin, ciprofloxacin, doxycycline, erythromycin, azithromycin and clarithromycin using 97 clinical isolates of Mycoplasma pneumoniae. MBCs of fluoroquinolones were determined for a subgroup of 12 isola...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2003-06, Vol.21 (6), p.574-577
Main Authors: Waites, Ken B., Crabb, Donna M., Duffy, Lynn B.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Fluoroquinolones
Fluoroquinolones - pharmacology
Macrolides
MBC
Medical sciences
MIC
Microbial Sensitivity Tests
Mycoplasma pneumoniae
Mycoplasma pneumoniae - drug effects
Mycoplasma pneumoniae - growth & development
Naphthyridines - pharmacology
Pharmacology. Drug treatments
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Summary:The MIC of gemifloxacin was compared with that of sparfloxacin, levofloxacin, moxifloxacin, gatifloxacin, ciprofloxacin, doxycycline, erythromycin, azithromycin and clarithromycin using 97 clinical isolates of Mycoplasma pneumoniae. MBCs of fluoroquinolones were determined for a subgroup of 12 isolates. Macrolides were the most potent agents with MIC 90s for all drugs ⩽0.001 mg/l. The doxycycline MIC 90 was 0.5 mg/l. Gemifloxacin MICs ranged from ⩽0.001 to 0.25 mg/l. The gemifloxacin MIC 90 (0.125 mg/l) was equivalent to moxifloxacin and gatifloxacin, was 2-fold lower than sparfloxacin, 8-fold lower than levofloxacin and 32-fold lower than ciprofloxacin. MBCs for gemifloxacin were predominantly within 2–4 times the corresponding MIC values, indicating a bactericidal effect.
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(03)00060-8