Extremely rare incidence of the UBQLN1 polymorphism (UBQ-8i) in Taiwan Chinese with Alzheimer's disease

• Published in: Neuroscience letters 2010-05, Vol.475 (2), p.108-109
• Main Authors: Chuo, Liang-Jen, Wu, Shwu-Tzy, Chang, Hong-I., Kuo, Yu-Min
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E4 - genetics; Asian Continental Ancestry Group; Biological and medical sciences; Carrier Proteins - genetics; Cell Cycle Proteins - genetics; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Fundamental and applied biological sciences. Psychology; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Medical sciences; Neurology; Polymorphism; Polymorphism, Single Nucleotide; Taiwan; Ubiquilin 1; Vertebrates: nervous system and sense organs
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2010.03.061

Recently, a single nucleotide polymorphism (SNP, A → G) in intron 8 of UBQLN 1 at the rs12344615 site (UBQ-8i) on chromosome 9q22 was associated with a higher risk of late-onset Alzheimer's disease (AD). Here, we aimed to investigate whether an association exists between the UBQ-8i polymorphism and AD in Taiwan Chinese. Initially, we included 100 late-onset AD patients and 100 gender- and age-matched non-demented (ND) control participants. The UBQ-8i polymorphism site was successfully determined in 91 AD and 96 ND individuals using the dye terminator nucleotide sequencing technique. Among the 187 participants, we did not detect any subject carrying the G allele. This finding is in agreement with the report listed in the NCBI SNP Reference Assembly, which states that