Cancer antigen 15/3: possible diagnostic use in veterinary clinical oncology. Preliminary study

The cancer antigen 15/3 is a mucin that is associated with the cell membrane, encoded by the MUC1 gene, and recognized by the monoclonal-clone DF3 antibody. The latter antigen was discovered to be specific for both the identification of human mammary neoplasia and during patient follow-up evaluation...

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Bibliographic Details
Published in:Veterinary research communications 2010-06, Vol.34 (Suppl 1), p.103-106
Main Authors: Marchesi, M. C, Manuali, E, Pacifico, E, Ferri, C, Romagnoli, M, Mangili, V, Fruganti, G
Format: Article
Language:English
Subjects:
Animals
antigens
Biomedical and Life Sciences
blood serum
cancer antigen 15/3
chemiluminescence
disease diagnosis
dog diseases
Dog Diseases - blood
Dog Diseases - diagnosis
Dog Diseases - metabolism
Dogs
Extended Abstract
Female
Life Sciences
Male
mammary neoplasms (animal)
monoclonal antibodies
Mucin-1 - metabolism
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - veterinary
Sex Characteristics
Veterinary Medicine/Veterinary Science
Zoology
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Summary:The cancer antigen 15/3 is a mucin that is associated with the cell membrane, encoded by the MUC1 gene, and recognized by the monoclonal-clone DF3 antibody. The latter antigen was discovered to be specific for both the identification of human mammary neoplasia and during patient follow-up evaluations. The aim of this study is to report and compare the results of the application of direct chemiluminescence in canine blood sera and the kit utilized in human medicine for the determination of Ca 15/3 to verify the diagnostic efficiency of the kit in cases presenting mammary tumors. Specifically, CA 15/3 has proven to be measurable in all samples assayed to distinguish clinically healthy subjects from those with mammary neoplasia.
ISSN:0165-7380
1573-7446
DOI:10.1007/s11259-010-9392-3