Baroreflex Sensitivity Predicts Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Without Structural Heart Disease

Background: Cardiovascular autonomic neuropathy is a major complication in patients with diabetes mellitus (DM). However, the relationship between cardiovascular autonomic neuropathy and the incidence of cardiovascular events has been poorly investigated in type 2 DM. The present study aimed to asse...

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Bibliographic Details
Published in:Circulation Journal 2010, Vol.74(7), pp.1379-1383
Main Authors: Okada, Norihiro, Takahashi, Naohiko, Yufu, Kunio, Murozono, Yukichi, Wakisaka, Osamu, Shinohara, Tetsuji, Anan, Futoshi, Nakagawa, Mikiko, Hara, Masahide, Saikawa, Tetsunori, Yoshimatsu, Hironobu
Format: Article
Language:English
Subjects:
Aged
Autonomic nervous system
Baroreflex - physiology
Baroreflex sensitivity
Cardiovascular Diseases - diagnosis
Cardiovascular event
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Female
Follow-Up Studies
Heart Diseases
Humans
Incidence
Japan
Male
Middle Aged
Phenylephrine
Predictive Value of Tests
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Summary:Background: Cardiovascular autonomic neuropathy is a major complication in patients with diabetes mellitus (DM). However, the relationship between cardiovascular autonomic neuropathy and the incidence of cardiovascular events has been poorly investigated in type 2 DM. The present study aimed to assess the long-term cardiovascular predictive value of baroreflex sensitivity (BRS) in Japanese patients with type 2 DM without structural heart disease. Methods and Results: BRS was evaluated using the phenylephrine method in 210 patients with type 2 DM who did not have structural heart disease or other severe complications. BRS was considered depressed if
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-09-0960