Drift and Mutation with a Finite Number of Allelic States

The frequencies with which alleles are alike within (Q) and between (q) populations are formulated for monoecious populations undergoing drift and mutation with unequal mutation rates among alleles for a finite number (k) of allelic states. The effective number of alleles and an application to Nei&#...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1984-01, Vol.81 (2), p.530-534
Main Author: Cockerham, C. Clark
Format: Article
Language:English
Subjects:
Alleles
Biological Sciences: Genetics
Evolution
Evolutionary genetics
Genetic distance
Genetic equilibrium
Genetic loci
Genetic mutation
Human genetics
Measuring instruments
Population genetics
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Summary:The frequencies with which alleles are alike within (Q) and between (q) populations are formulated for monoecious populations undergoing drift and mutation with unequal mutation rates among alleles for a finite number (k) of allelic states. The effective number of alleles and an application to Nei's measure of genetic distance [Nei, M. (1972) Am. Nat. 106, 283-292] are also considered for this model. The equilibrium values of Q and q increase as k decreases. Unequal mutation rates further increase the equilibrium values and reduce the rates of approach of Q and q to these values. The transitional values of Q and q are very dependent on the initial population frequency composition when mutation rates are unequal. Reducing k, of course, reduces the effective number of alleles, which is further reduced by unequal mutation rates. Complications introduced by initial population composition, unequal mutation rates, and number of allelic states, coupled with data limitations for long-term measures of genetic distance or population differentiation, with mutation as the main driving force, are discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.81.2.530