Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review

Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabol...

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Bibliographic Details
Published in:Applied biochemistry and biotechnology 2010-03, Vol.160 (6), p.1699-1722
Main Authors: Asha, Sepuri, Vidyavathi, Maravajhala
Format: Article
Language:English
Subjects:
Biochemistry
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Chemistry
Chemistry and Materials Science
drug evaluation
drugs
Experiments
Fundamental and applied biological sciences. Psychology
Hepatocytes - metabolism
Humans
Kinetics
Liver
Liver - metabolism
liver microsomes
Metabolism
Metabolites
Methods. Procedures. Technologies
Microsomes, Liver - enzymology
Microsomes, Liver - metabolism
Perfusion
Pharmaceutical Preparations - metabolism
pharmacokinetics
Pharmacology
probability
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Summary:Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabolism and inhibition studies. The methodology for these studies using human liver microsomes, applications of human liver microsomes, and the drugs studied by human liver microsomes are listed. Human liver microsomes represent a critical experimental model for the evaluation of drug metabolites with a high probability of clinical success.
ISSN:0273-2289
1559-0291
DOI:10.1007/s12010-009-8689-6