Alcohol consumption and metabolic syndrome in the elderly: results from the Italian longitudinal study on aging

• Published in: European journal of clinical nutrition 2010-03, Vol.64 (3), p.297-307
• Main Authors: Buja, A, Scafato, E, Sergi, G, Maggi, S, Suhad, M A, Rausa, G, Coin, A, Baldi, I, Manzato, E, Galluzzo, L, Enzi, G, Perissinotto, E
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aging; Aging - physiology; Alcohol; Alcohol Drinking - adverse effects; Alcohol Drinking - epidemiology; Alcohol use; Alcohols; ATP; Biological and medical sciences; Blood glucose; Blood pressure; Cardiovascular diseases; Clinical Nutrition; Cohort Studies; Comorbidity; Complications and side effects; Demographic aspects; Development and progression; Dose-Response Relationship, Drug; Drinking of alcoholic beverages; Epidemiology; Ethanol - pharmacology; Feeding. Feeding behavior; Female; Females; Food and nutrition; Fundamental and applied biological sciences. Psychology; Gender; Geriatric Assessment; Geriatrics; Health aspects; Health Surveys; Humans; Incidence; Internal Medicine; Italy - epidemiology; Longitudinal Studies; Male; Males; Medical sciences; Medicine; Medicine & Public Health; Men; Metabolic Diseases; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Metabolic syndrome X; Metabolism; Miscellaneous; Odds Ratio; Older people; original-article; Other metabolic disorders; Population studies; Prevalence; Public Health; Risk Assessment; Risk Factors; Sex Factors; Statistical analysis; Systolic pressure; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Women
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2009.136

Background/Objectives: Although there is plenty of evidence of the association between metabolic syndrome (MS) and cardiovascular disease, the relationship between alcohol consumption and MS is still questioned. The few publications with respect to the elderly seem to indicate that alcohol consumption is unassociated with MS. The aim of this study was to assess the association between alcohol consumption and the prevalence and incidence of MS, as well as its components in a large sample of Italian elderly people. Subjects/Methods: This is a multicenter study on a population-based sample of Italian people aged 65–84 years. The Italian Longitudinal Study on Aging (ILSA) included a prevalence phase in 1992 and an incidence phase from 1995 to 1996. The median length of follow-up was 3.5 years. In the present study, the analysis included 1321 men grouped into five alcohol consumption classes: abstainers, and those consuming ⩽12, 13–24, 25–47 or ⩾48 g of alcohol in a day. Among the 1122 women considered, the last two of the above five categories were pooled together (>24 g/day). MS was defined according to ATP III criteria. All statistical analyses were stratified by gender. Results: Adjusted odds ratios showed that categorized alcohol consumption was not significantly associated with the prevalence and incidence of MS when compared with abstainers in either gender. For the MS incidence survey, three of five components (systolic pressure, glycemia and waist circumference) proved to be significantly and harmfully affected by alcohol consumption in males, whereas no such significant association emerged in females. Conclusions: These results suggest that alcohol can modify an individual's metabolic condition and that, even among the elderly, men might be more sensitive to the effects of alcohol than women.