Pityriasis lichenoides et varioliformis acuta: a disease spectrum

Pityriasis lichenoides et varioliformis acuta (PLEVA), or Mucha–Habermann disease (MHD), is a cutaneous disorder evident with crops of erythematous macules and papules, usually on the trunk and flexural areas of the extremities. Its etiology remains unknown. PLEVA is speculated to be an inflammatory...

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Bibliographic Details
Published in:International journal of dermatology 2010-03, Vol.49 (3), p.257-261
Main Authors: Fernandes, Neil F., Rozdeba, Paul J., Schwartz, Robert A., Kihiczak, George, Lambert, W. Clark
Format: Article
Language:English
Subjects:
Adolescent
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
Dermatology
Erythromycin - therapeutic use
Histamine Antagonists - therapeutic use
Humans
Medical sciences
Middle Aged
Phototherapy
Pityriasis Lichenoides - diagnosis
Pityriasis Lichenoides - drug therapy
Pityriasis Lichenoides - pathology
Psoriasis. Parapsoriasis. Lichen
Tacrolimus - therapeutic use
Tetracycline - therapeutic use
Young Adult
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Summary:Pityriasis lichenoides et varioliformis acuta (PLEVA), or Mucha–Habermann disease (MHD), is a cutaneous disorder evident with crops of erythematous macules and papules, usually on the trunk and flexural areas of the extremities. Its etiology remains unknown. PLEVA is speculated to be an inflammatory reaction triggered by certain infectious agents, an inflammatory response secondary to T‐cell dyscrasia, or an immune complex‐mediated hypersensitivity. Histologic examination of a skin biopsy specimen is the standard for the identification of PLEVA, but definitive diagnosis may be difficult. Apart from the febrile ulcerative variant, which may be fatal, PLEVA tends to be self‐limited in its course. Treatment is targeted mainly at the symptomatic relief of pruritus.
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4632.2008.03915.x