Three New Indole Alkaloids from Trigonostemon lii

Three unprecedented indole alkaloids, trigonoliimines A−C (1−3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1−3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed mod...

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Bibliographic Details
Published in:Organic letters 2010-05, Vol.12 (10), p.2370-2373
Main Authors: Tan, Cheng-Jian, Di, Ying-Tong, Wang, Yue-Hu, Zhang, Yu, Si, Yi-Kang, Zhang, Qiang, Gao, Suo, Hu, Xu-Jia, Fang, Xin, Li, Shi-Fei, Hao, Xiao-Jiang
Format: Article
Language:English
Subjects:
Anti-HIV Agents - chemistry
Anti-HIV Agents - isolation & purification
Anti-HIV Agents - pharmacology
Euphorbiaceae - chemistry
HIV-1 - drug effects
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Indole Alkaloids - pharmacology
Microbial Sensitivity Tests
Molecular Conformation
Plant Leaves - chemistry
Stereoisomerism
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Summary:Three unprecedented indole alkaloids, trigonoliimines A−C (1−3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1−3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC50 = 0.95 μg/mL, TI = 7.9).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100715x