Oncocytic adrenocortical carcinoma

Abstract Only 17 cases of oncocytic adrenocortical carcinoma have been reported in the English literature. Here, we report an incidental case of oncocytic adrenocortical carcinoma. The patient was a 69-year-old man with the chief complaint of abdominal pain. Abdominal computed tomography revealed a...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2010-06, Vol.14 (3), p.204-208
Main Authors: Ohtake, Hiroya, MD, PhD, Kawamura, Hiroshi, MD, PhD, Matsuzaki, Masami, MD, PhD, Yokoyama, Eiichi, MD, Kitajima, Masayuki, MD, Onizuka, Shiro, MD, PhD, Yamakawa, Mitsunori, MD, PhD
Format: Article
Language:English
Subjects:
Adenoma, Oxyphilic - metabolism
Adenoma, Oxyphilic - pathology
Adenoma, Oxyphilic - surgery
Adrenal Cortex Neoplasms - metabolism
Adrenal Cortex Neoplasms - pathology
Adrenal Cortex Neoplasms - surgery
Adrenal gland
Adrenocortical Carcinoma - metabolism
Adrenocortical Carcinoma - pathology
Adrenocortical Carcinoma - surgery
Aged
Autoantibodies - analysis
Biomarkers, Tumor - metabolism
Bisceglia's criteria
Cell Nucleus - metabolism
Cell Nucleus - pathology
Humans
Immunohistochemistry
Incidental Findings
Male
Mitochondria - immunology
Oncocytic adrenocortical carcinoma
Pathology
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Summary:Abstract Only 17 cases of oncocytic adrenocortical carcinoma have been reported in the English literature. Here, we report an incidental case of oncocytic adrenocortical carcinoma. The patient was a 69-year-old man with the chief complaint of abdominal pain. Abdominal computed tomography revealed a left adrenal tumor. No hormonal symptoms were observed. The excised tumor was whitish, encapsulated, and 75 × 60 × 45 mm in size. Large polygonal tumor cells were arranged in a generally diffuse architecture and exhibited abundant eosinophilic granular cytoplasm. Nuclear atypia with atypical mitotic figures and capsular and sinusoidal invasions were observed. The tumor cells were immunopositive for vimentin, neuron-specific enolase, and synaptophysin but not for α -inhibin, melan A, or p53. Diffuse and strong immunopositivity with an antimitochondrial antibody proved that this tumor was truly oncocytic. Upon review of previous cases of oncocytic adrenocortical tumors, we reconsidered the diagnostic findings of the potential for malignancy.
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2009.06.006