Biology of FasL

FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of Fas...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2003-06, Vol.14 (3), p.325-335
Main Authors: Lee, Hae-ock, Ferguson, Thomas A.
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Autoantibodies - biosynthesis
CTL
Cytotoxicity, Immunologic
Fas Ligand Protein
FasL
Homeostasis
Humans
Immune privilege
Immune Tolerance
Membrane Glycoproteins - genetics
Membrane Glycoproteins - immunology
Membrane Glycoproteins - physiology
Mice
Mice, Mutant Strains
Models, Immunological
Mutation
Neoplasms - immunology
Neovascularization, Pathologic
T-Lymphocytes - immunology
Tumor progression
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Summary:FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of FasL regulation has been expanded to angiogenesis and tumor progression. Here, we review what is currently known about the role of FasL in many areas of biology.
ISSN:1359-6101
DOI:10.1016/S1359-6101(03)00028-5