Prenylated isoflavonoids from Millettia pervilleana

• Published in: Phytochemistry (Oxford) 2003-06, Vol.63 (4), p.471-474
• Main Authors: Palazzino, Giovanna, Rasoanaivo, Philippe, Federici, Elena, Nicoletti, Marcello, Galeffi, Corrado
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; Chemical constitution; Coumarins; Coumarins - chemistry; Coumarins - isolation & purification; Cytotoxic and anti-cancer activity; Drug Screening Assays, Antitumor; Fundamental and applied biological sciences. Psychology; Humans; Isoflavones - chemistry; Isoflavones - isolation & purification; Isoflavones - pharmacology; Leguminosae; Millettia - chemistry; Millettia pervilleana; Nuclear Magnetic Resonance, Biomolecular; Pervilleanine; Pervilline; Pervillinine; Plant Bark - chemistry; Plant physiology and development; Plant Roots - chemistry; Plants, Medicinal - chemistry; Pterocarpans; Pterocarpans - chemistry; Pterocarpans - isolation & purification; Rotenone - chemistry; Rotenone - isolation & purification; Rotenone - pharmacology; Tumor Cells, Cultured
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(02)00489-2

From the root bark of Millettia pervilleana, which had shown significant cytotoxic activity, a 3-phenylcoumarin, named pervilleanine, two new pterocarpans, pervilline and pervillinine, and one known, emoroidocarpan, were isolated in addition to rotenone and 3α-hydroxyrotenone. The anticancer activity of two previously isolated isoflavanones, pervilleanone and 3′- O-demethylpervilleanone is reported. From the root bark of Millettia pervilleana a 3-phenylcoumarin, pervilleanine, and two pterocarpans, pervilline and pervillinine, were isolated. The anticancer activity of previously isolated pervilleanone and 3′- O-demethylpervilleanone is reported.