ADP‐degrading enzymes inhibit platelet activation in bile duct‐ligated rats

Background: The effect of cholestatic liver disease on primary hemostasis function remains ill‐defined. Objectives: To determine platelet function and identify the mechanisms involved in the observed platelet function in cholestatic rats. Methods: Platelet function was studied in a model of 2‐week b...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2010-02, Vol.8 (2), p.360-368
Main Authors: WITTERS, P., HOYLAERTS, M., FRESON, K., DE VOS, R., VAN PELT, J., NEVENS, F., VAN GEET, C., CASSIMAN, D.
Format: Article
Language:English
Subjects:
5'-Nucleotidase - blood
Adenosine Diphosphate - blood
ADP
Alkaline Phosphatase - blood
Animals
Bile Ducts - surgery
Blood Platelets - enzymology
Blood Platelets - ultrastructure
Cholestasis - blood
Cholestasis - enzymology
Cholestasis - pathology
cholestatic liver disease
Collagen
Disease Models, Animal
hemostasis
Humans
Ligation
phosphatase
Platelet Aggregation
Platelet Count
platelet function
Rats
Rats, Wistar
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: The effect of cholestatic liver disease on primary hemostasis function remains ill‐defined. Objectives: To determine platelet function and identify the mechanisms involved in the observed platelet function in cholestatic rats. Methods: Platelet function was studied in a model of 2‐week bile duct ligation and compared to that in sham‐operated rats with and without a storage pool defect. Results: ADP‐induced and collagen‐induced platelet aggregation were clearly impaired following bile duct ligation (P 
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2009.03684.x