Differential Presentations, Clinical Courses, and Survivals of Osteosarcomas of the Proximal Humerus over Other Extremity Locations

Background Although there are controversies about the prognosis of proximal humeral osteosarcoma, our previous study showed poor survival in those patients. In the present study, we undertook to determine why this site is associated with a poor outcome and to identify the clinicopathologic variables...

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Bibliographic Details
Published in:Annals of surgical oncology 2010-03, Vol.17 (3), p.702-708
Main Authors: Cho, Wan Hyeong, Song, Won Seok, Jeon, Dae-Geun, Kong, Chang-Bae, Kim, Min Suk, Lee, Jun Ah, Yoo, Ji Young, Kim, Jae Do, Lee, Soo-Yong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bone and Soft Tissue Sarcomas
Bone Neoplasms - mortality
Bone Neoplasms - pathology
Bone Neoplasms - surgery
Child
Child, Preschool
Extremities - pathology
Extremities - surgery
Female
Humans
Humerus - pathology
Humerus - surgery
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Oncology
Osteosarcoma - mortality
Osteosarcoma - pathology
Osteosarcoma - surgery
Prognosis
Surgery
Surgical Oncology
Survival Rate
Tumor Burden
Young Adult
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Summary:Background Although there are controversies about the prognosis of proximal humeral osteosarcoma, our previous study showed poor survival in those patients. In the present study, we undertook to determine why this site is associated with a poor outcome and to identify the clinicopathologic variables involved. Methods The study cohort consisted of 36 proximal humeral and 341 other extremity American Joint Committee on Cancer (AJCC) stage II osteosarcomas. We examined the clinicopathologic differences between these osteosarcomas. The prognostic significances of factors identified for a proximal humoral location were evaluated by survival analysis of all 377 patients. Results Patients with a proximal humeral osteosarcoma had the following characteristics: a higher incidence of pathologic fracture ( P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-009-0825-6