TNF-α promoter polymorphisms in multiple sclerosis: no association with −308 and −238 alleles, but the −857 alleles in associated with the disease in Turkish patients

Summary Dysregulation in the expression of pro‐ and anti‐inflammatory cytokines is one of the milestones in multiple sclerosis (MS) development and progression. Tumour necrosis factor (TNF‐α), a proinflammatory cytokine is believed to play an important role in MS pathogenesis. The objective of this...

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Bibliographic Details
Published in:International journal of immunogenetics 2010-04, Vol.37 (2), p.91-95
Main Authors: Akcali, A., Pehlivan, S., Pehlivan, M., Sever, T., Akgul, P., Neyal, M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Multiple Sclerosis - genetics
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Promoter Regions, Genetic - genetics
Tumor Necrosis Factor-alpha - genetics
Turkey
Young Adult
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Summary:Summary Dysregulation in the expression of pro‐ and anti‐inflammatory cytokines is one of the milestones in multiple sclerosis (MS) development and progression. Tumour necrosis factor (TNF‐α), a proinflammatory cytokine is believed to play an important role in MS pathogenesis. The objective of this study is to investigate the association between TNF‐α promoter region (TNF‐α−238, −308 and −857) and susceptibility to MS and clinical course of the disease. Eighty‐six relapsing remitting MS patients and 150 sex‐, age‐ and ethnic‐matched controls were enrolled in the study. Genotyping was performed by PCR‐RFLP method. We observed a statistically significant increase in TNF‐α 857 CC genotype in MS patients than controls (P 
ISSN:1744-3121
1744-313X
DOI:10.1111/j.1744-313X.2009.00895.x