Abscisic Acid: Emergence of a Core Signaling Network

Abscisic acid (ABA) regulates numerous developmental processes and adaptive stress responses in plants. Many ABA signaling components have been identified, but their interconnections and a consensus on the structure of the ABA signaling network have eluded researchers. Recently, several advances hav...

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Bibliographic Details
Published in:Annual review of plant biology 2010-01, Vol.61 (1), p.651-679
Main Authors: Cutler, Sean R, Rodriguez, Pedro L, Finkelstein, Ruth R, Abrams, Suzanne R
Format: Article
Language:English
Subjects:
Abscisic acid
Abscisic Acid - metabolism
biochemical pathways
Gene Expression Regulation, Plant
Kinases
literature reviews
mechanism of action
phosphatases
plant adaptation
Plant biology
plant development
plant hormones
plant physiology
plant stress
plants
Plants - metabolism
protein structure
receptors
Signal Transduction
stress tolerance
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Summary:Abscisic acid (ABA) regulates numerous developmental processes and adaptive stress responses in plants. Many ABA signaling components have been identified, but their interconnections and a consensus on the structure of the ABA signaling network have eluded researchers. Recently, several advances have led to the identification of ABA receptors and their three-dimensional structures, and an understanding of how key regulatory phosphatase and kinase activities are controlled by ABA. A new model for ABA action has been proposed and validated, in which the soluble PYR/PYL/RCAR receptors function at the apex of a negative regulatory pathway to directly regulate PP2C phosphatases, which in turn directly regulate SnRK2 kinases. This model unifies many previously defined signaling components and highlights the importance of future work focused on defining the direct targets of SnRK2s and PP2Cs, dissecting the mechanisms of hormone interactions (i.e., cross talk) and defining connections between this new negative regulatory pathway and other factors implicated in ABA signaling.
ISSN:1543-5008
1545-2123
DOI:10.1146/annurev-arplant-042809-112122