C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase

C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular...

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Bibliographic Details
Published in:FEBS letters 2010-03, Vol.584 (5), p.968-972
Main Authors: Lee, Wan, Kim, Mi-Jin, Park, Eun-Ju, Choi, Young-Jin, Park, Seung-Yoon
Format: Article
Language:English
Subjects:
ACC
Acetyl-CoA Carboxylase - metabolism
Adipokines - chemistry
Adipokines - genetics
Adipokines - metabolism
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
C1QTNF6
Cell Line
CTRP-6
Fatty acid oxidation
Fatty Acids - metabolism
Humans
Lipid Metabolism - genetics
Lipid Metabolism - physiology
Mice
Muscle
Muscle Cells - metabolism
Oxidation-Reduction
Phosphorylation
Protein Structure, Tertiary - genetics
Protein Structure, Tertiary - physiology
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Signal Transduction - genetics
Signal Transduction - physiology
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Summary:C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) in skeletal muscle cells. In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes. Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2010.01.040